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Thrombocytopenia

  • Criteria

    • plt < 150k
  • Don't miss

    • HIT, HIV, DIC
  • ROS

    • bleeding, nutrition, fever, nightsweats, rash, recent infection, recent heparin
  • Ddx

    • nutritional deficiency (fatigue, pallor, anemia)
      • B12 deficiency
      • folate deficiency
      • iron deficiency
    • marrow dysfunction
      • myelofibrosis
      • leukemia
      • lymphoma (lymphadenopathy)
      • MDS
      • metastatic cancer
      • viral infections
        • flu
        • mono (fatigue, splenomegaly)
        • HIV
        • measles, rubella
      • chemo
      • radiation
      • aplastic anemia
      • Fanconi's anemia
      • Wiskott-Aldrich (eczema)
    • peripheral destruction/sequestration
      • HIT (recent heparin)
      • ITP (petechiae)
      • TTP/HUS (purpura)
      • DIC (shock)
      • SLE
      • splenic sequestration (splenomegaly)
      • prosthetic valves
    • pseudothrombocytopenia (normal plt on smear)
      • platelet agglutinins, rosettes
      • giant megakaryocytes
    • other
      • hereditary thrombocytopenia

  • Print | Citations

    Disclaimer: MDHero Workups is for educational use only, and is not meant to replace the clinical judgement of a professional. We do not guarantee the accuracy of any information on this website.